children's cough variant asthma
Conditions
Interventions
High-dose group:''xiaoer Ma-Long-Zhi-Ke-Ping-Chuan Granules''
Low Dose Group:''xiaoer Ma-Long-Zhi-Ke-Ping-Chuan Granules'' + simulate
Placebo Group:''xiaoer Ma-Long-Zhi-Ke-Ping-Chuan Granules'' simulate
Sponsors
Shanghai Municipal Hospital of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
4 Years to 7 Years
Inclusion criteria
Inclusion criteria: 1. According with the Western diagnostic criteria of cough variant asthma in children; 2. Standard of syndrome differentiation of traditional Chinese medicine in accordance with phlegm-heat retention of Lung Syndrome; 3. Cough severity (day and night) score >=4; 4. Between the ages of 4 and 7 years; 5. The process of informed consent is in compliance with the relevant provisions, and the legal guardian signs the informed consent.
Exclusion criteria
Exclusion criteria: 1. Chronic cough caused by acid reflux disease cough, psychogenic cough, drug induced cough, otogenic cough, congenital respiratory disease, foreign body inhalation, respiratory tract infection caused by specific pathogens, persistent bacterial bronchitis, etc. , and patients with Upper Airway Cough Syndrome alone; 2. During 2 weeks prior to selection, asthma control treatments such as inhalation of Glucocorticoid, leukotriene modulators, long acting 2 receptor agonists, slow release theophylline, and systemic glucocorticoid were used; Those who had taken antihistamines, antiallergic drugs, systemic fast-acting 2-receptor agonists, theophylline within 1 week before being selected, as well as traditional Chinese medicines (including decoction, decoction pieces, prescription granules and proprietary Chinese medicines) with antitussive, expectorant and antiasthmatic effects; 3. Patients with severe malnutrition, Rachitis and complicated primary diseases of heart, brain, liver, kidney and Hematopoiesis, especially those with AST, ALT, SCR > the upper limit of normal value; 4. Persons Allergic to experimental drugs and their components; 5. Patients in other clinical trials within 1 month; 6. The researchers did not consider it appropriate to participate in this clinical trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cough severity (day and night) score;Onset time and efficiency of cough;Duration and rate of cough relief; | — |
Secondary
| Measure | Time frame |
|---|---|
| Reduction in number and usage of pharmaceutical products;TCM syndrome integral;Single symptom of traditional Chinese Medicine; | — |
Countries
China
Contacts
Public ContactXue Zheng
Shanghai Municipal Hospital of Traditional Chinese Medicine
Outcome results
None listed