knee osteoarthritis
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1. In line with the KOA diagnostic standard established by ARA. 2. Aged >= 40 years, male or female; 3. Knee OA fulfilling the ACR classification criteria, Kellgren & Lawrence class rating of II, and III; 4. Those who are willing to participant in this trial and sign informed consent.
Exclusion criteria
Exclusion criteria: 1. Rheumatoid arthritis, gouty arthritis, infectious arthritis or other joint diseases; 2. Patients with local skin ulceration, skin infection, severe surgical or traumatic scar, local malignant tumor of knee joint or joint replacement; 3. Patients with joint pain and dysfunction caused by other causes; 4. Patients with active peptic ulcer and bleeding, severe renal and liver dysfunction or bleeding tendency of coagulation dysfunction; 5. Patients with serious organic heart disease, such as myocardial infarction, heart failure, serious arrhythmia, pacemaker implantation or hypertension without treatment or drug control; 6. Patients with severe neurological or mental diseases who cannot cooperate with doctors; 7. Patients with systemic collagen connective tissue diseases, such as systemic lupus erythematosus, etc.; 8. Patients unable to understand the questionnaire; 9. Current or past (within 6 months) oral or intra-articular corticosteroid use; 10. A history of taking NSAIDs or symptomatic slow-acting drugs for OA (diacerein, hyaluronic acid) within the previous 2 weeks.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| WOMAC; | — |
Secondary
| Measure | Time frame |
|---|---|
| VAS;Global rating of change score;Timed up and go test;Range of motion; | — |
Countries
China
Contacts
The Second Affiliated Hospital of Chongqing Medical University