Novel Coronavirus Pneumonia (COVID-19)
Conditions
Interventions
severe group:high dose intravenous vitamin C
critical group:high dose intravenous vitamin C
Sponsors
Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. patients who was diagnosed with COVID-19 pneumonia with severe and critical severity. Diagnosis were performed according to World Health Organization interim guidance11. The specific criteria for severity classification3 is shown in supplementary table 1; 2. patients who suffered with disease aggravation which was defined: the severe patients showed continuous falling down of PF indicators and enlargement of radiological lesion >50% for 3 days with high risk of higher level of respiratory support; the critical patients with continuous falling down with PF indicators even in the treatment of mechanical ventilation (MV) or extracorporeal membrane oxygenation (ECMO); 3. patients who received HDIVC within 1 day after aggravation. The aggravation occurrence and the initiation of HDIVC rescue therapy was judged by the same expert panel.
Exclusion criteria
Exclusion criteria: 1. During the treatment, the tumor occurred; 2. During pregnancy or lactation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| C-reactive protein;lymphocyte;CD4+ T cell;PaO2/FiO2; | — |
Countries
China
Contacts
Public ContactEnqiang Mao
Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine
Outcome results
None listed