Skip to content

A split-mouth randomized controlled clinical study of applying CGF to repair distal bone defect of mandibular second molar after the extraction of impacted mandibular third molar

A split-mouth randomized controlled clinical study of applying CGF to repair distal bone defect of mandibular second molar after the extraction of impacted mandibular third molar

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2000032687
Enrollment
Unknown
Registered
2020-05-07
Start date
2020-09-30
Completion date
Unknown
Last updated
2020-05-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Fully-impacted mandibular third molar

Interventions

experimental group:Exsanguinate the patient's own blood to prepare for CGF and then put CGF into distal side of mandibular second molar in the operating area after the extraction of fully-impacted man
control group:Directly suture the wound after the extraction of fully-impacted mandibular third molar.

Sponsors

Oral and Maxillofacial Surgery, the Affiliated Stomatology of Tongji University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 50 Years

Inclusion criteria

Inclusion criteria: 1. The patient is aged from 18 to 50 years old with no limit of gender and needs the extraction of impacted mandibular third molar. 2. The patient's unilateral or bilateral mandibular third molars are both fully-impacted. 3. The patient's distal intrabony defect of unilateral or bilateral mandibular second molars adjacent to mandibular third molars are > 4mm. 4. The patient's unilateral or bilateral mandibular third molars are low-level mesial/horizontal impacted, and the sagittal inclination of them are >= 50 degrees. 5. The imaging results show that the area where distal roots of mandibular second molars contact with mandibular third molars have preoprative absorption. 6. The patient volunteer to participate in this clinical trial and is able to take follow-ups on time. 7. The patient is able to consciously keep operating area clean and maintain oral hygiene.

Exclusion criteria

Exclusion criteria: 1. The patient's unilateral or bilateral mandibular second molar is III degrees loosened,fractured, or has incomplete root canal treatment history or severe apical inflammation causing it unable to keep. 2. The patient's unilateral or bilateral mandibular second molar has Amalgam filling which infects the imaging results. 3. The patient's unilateral or bilateral mandibular second molar has severe undercontrolled periodontal disease. 4. There is dentigerous cyst or other oral maxilofical tumors around the patient's mandibular third molar. Or the patient is in the treatment of other oral and maxillofacial tumors. 5. The patient has an uncontrolled history of diabetes, alcohol abuse, blood disease, severe smoking, mental illness or other serious systemic diseases. 6. The patient is pregnant or in lactation or prepares to be pregnant during the trial. 7. The patient's operating area has acute inflammation such as pericoronitis or mandibular alveolar abscess. Or the operating area has history of long-term chronic pericoronitis or apical periodontitis. 8. The patient is under orthodontic treatment. 9. The patient cannot follow doctor's orders and coorparate in the trial,which causes the incompletion of data collection and record thus infect the results of the trial.

Design outcomes

Primary

MeasureTime frame
distal probing pocket depth of mandibular second molar;distal intrabony defect of mandibular second molar;distal osseous defect depth of mandibular second molar;

Countries

China

Contacts

Public ContactKang Feiwu

Oral and Maxillofacial Surgery, the Affiliated Stomatology of Tongji University

kfw@tongji.edu.cn+86 13817533108

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026