osteoporosis
Conditions
Interventions
Group A:Subcutaneous injection of PTH
Group B:Intravenous bisphosphonates
Sponsors
Army Medical Center of PLA
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Aged >= 50 years, and the female should reach menopause for at least 1 year; 2. In line with the diagnostic criteria of severe osteoporosis, the results of DXA bone mineral density examination suggested that the t-value of one of the effective sites (lumbar 1-4, femur neck, total hip) was less than -1.0; 3. With at least one or more vertebral compression fractures (low-trauma fractures).
Exclusion criteria
Exclusion criteria: 1. Patients with osteomalacia; 2. Renal insufficiency was found at baseline, eGFR <= 35ml/min/1.73m2; 3. Hyperthyroidism, hyperparathyroidism, adrenocortical hypofunction, hypophysis; 4. Patients with hypercalcemia at baseline; 5. Patients diagnosed with bone tumor or tumor bone metastasis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Bone mineral density;Bone metabolism;liver function;renal function;Blood biochemistry;VAS;ODI; | — |
Countries
China
Contacts
Public ContactLiu Peng
Outcome results
None listed