Postpartum depression
Conditions
Interventions
Group K:Perioperative and postoperative analgesia pumps use of esketamine
Group KD:Perioperative and postoperative analgesia pumps use of esketamine and dexmedetomidine
Sponsors
The First Affiliated Hospital of Zhengzhou University
Eligibility
Sex/Gender
Female
Age
20 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1) Maternal with ASA grade I-II; 2) Maternal for cesarean section; 3) Maternal age is 20 ~ 45 years old; 4) 28-42 weeks of gestational age; 5) Preoperative Edinburgh Postpartum Depression Rating Scale score > 9; 6) Single-born pregnant primipara; 7)Willing to participate in this trial and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1) Pregnancy through assisted reproduction; 2) Maternal women have serious obstetric complications or serious underlying diseases; 3) History of ketamine abuse or dependence, drug or alcohol dependence for more than 6 months; 4) Allergy to research related drugs; 5) With a history of mental illness or depression in other life stages.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Depression score;Postoperative analgesic pump dosage;VAS score;Plasma BDNF factor levels;intraoperative (Operation time, perioperative heart rate and blood pressure changes, intraoperative oxygen saturation);Adverse reactions; | — |
Countries
China
Contacts
Public ContactYanqiu Ai
The First Affiliated Hospital of Zhengzhou University
Outcome results
None listed