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Comparison of programmed intermittent epidural boluses with continuous epidural infusion for the relief of uterine contraction pain after cesarean section: a randomized, controlled, double-blind trial

Programmed intermittent epidural bolus in comparison with continuous epidural infusion for uterine contractions pain relief after caesarean section: a randomised, double-blind clinical trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2000032645
Enrollment
Unknown
Registered
2020-05-04
Start date
2020-06-01
Completion date
Unknown
Last updated
2021-03-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Uterine contractions pain after cesarean sectio

Interventions

PIEB group:Programmed intermittent epidural bolus
CEI group:Continuous epidural infusion

Sponsors

Guangzhou Women and Children's Medical Center
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 45 Years

Inclusion criteria

Inclusion criteria: 1) Elective for cesarean section under combined spinal and epidural anesthesia; 2) term gestation (>= 37 weeks), singleton pregnancy; 3) ASA physical status I or II; 4) Aged 18 to 45 years; 5) Patients are willing to participate in the trial and signed the informed consent; 6) Nulliparous (parity=0) or primiparous (parity=1); 7)Planned breastfeeding after surgery.

Exclusion criteria

Exclusion criteria: 1) Body mass index >= 40 kg/m2; 2) Contraindications to spinal anesthesia (increased intracranial pressure, coagulopathy, or local skin infection); 3) Participant received antipsychotic or hypnotic medications, alcohol or drug abuse; 4) Severe pregnancy complications (gestational diabetes, gestational hypertension, heart disease, complete placenta previa, placental abruption, preeclampsia); 5) Use of Sedative or analgesic drugs 2 hours before surgery; 6) Allergy,intolerance or contraindication to drugs used in the study; 7) Known fetal abnormalities.

Design outcomes

Primary

MeasureTime frame
Uterine contraction pain during breast feeding (VAS-UD) at 36 h after the operation;—

Secondary

MeasureTime frame
Uterine contraction pain during breast feeding (VAS-UD) at 2 h, 6 h, 12 h and 24 h after the operation;uterine contraction pain before breastfeeding (VAS-UB);Wound pain at rest (VAS-R) after cesarean section;Provocative wound while changing position in bed (VAS-P) after cesarean sectionafter cesarean section;Motor blockade;PCEA requested and received bolus per 12 h;Ropivacaine consumption;Time to first requested/received PCEA;The time to use diclofenac potassium suppository;Number of diclofenac potassium suppository request;Postoperative adverse reactions;uterine hemorrhage up to 24 h (mL) after surgery;Satisfaction with analgesia;Time to first exhaust;Time to first urination after the extubation of the catheters;Uterotonic agents administered during and after surgery;Uterotonic agents administered during and after surgery;—

Countries

China

Contacts

Public ContactMo XiaoFei

Guangzhou Women and Children's Medical Center

13560336485@163.com+86 13560336485

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026