Bone defect
Conditions
Interventions
Experimental group:Customized bone block grafts
Control group:Autogenous bone block grafts
Sponsors
West China Hospital of Stomatology
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1) Male or female patients aged 18 to 60 years (including 18 and 60 years); 2) More than 3 months after tooth extraction; 3) One-wall horizontal bone defect or vertical bone defect; 4) Subjects are fully aware of the benefits and risks of this trial and are willing to participate and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1) Heart disease (heart function disease of grade II and above); Abnormal liver and kidney function (ALT and AST > 1.5 times the upper limit of normal value; patients with diabetes, poor control of blood glucose level (fasting blood glucose is still >= 8.0mmol /L after control); 2) Patients with uncontrolled oral diseases, such as progressive periodontal disease, severe periapical infection, and severe habitual molar disease; 3) Uncontrolled metabolic diseases such as diabetes, rickets, thyroid disease, and severe liver and kidney dysfunction. 4) Patients with osteoporosis, osteomalacia and osteosclerosis; 5) Malignant tumors, active infectious lesions, and bone defects in the active phase of metabolic bone disease; 6) Systemic infection or local acute infection of the surgical site; 7) Aplastic anemia and other blood diseases, taking anticoagulant drugs or coagulation tests for 3 months is not within the normal range; 8) The use of drugs that may affect the healing of hard and soft tissues, such as long-term use of sedative hypnotics (continuous use for more than 3 months), long-term use of non-steroidal anti-inflammatory drugs or adrenal corticosteroids (continuous use for more than 3 months), and the treatment of patients who have received drugs in the current or recent 3 months that may affect or promote bone metabolism; 9) Patients with severe smoking (smoking more than 20 cigarettes/day) in the past 6 months and during bone healing; 10) Autoimmune diseases; 11) Radiation therapy is under way; 12) Mental illness, drug abuse and alcohol abuse; 13) Known allergic to the materials used in the product; 14) Women in pregnancy or lactation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Bone thickness; | — |
Secondary
| Measure | Time frame |
|---|---|
| Soft tissue contour;Bone healing of bone graft materials;Operating time;Postoperative pain;Wound Healing; | — |
Countries
China
Contacts
Public ContactMo Anchun
West China Hospital of Stomatology
Outcome results
None listed