Traumatic Brain Injury
Conditions
Interventions
Optimal CPP Guided Treatment group:set the CPP at the optimal CPP level
control group:set CPP at 60-70 mmHg
Sponsors
Shanghai Jiaotong University Affiliated Sixth People's Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients agreed to participate and signed informed consent forms. 2. Adult patients (range from 18 to 76 years old) with closed traumatic brain injury, who were admitted in 48 hours. 3. Patients underwent intraparenchymal or intraventricular ICP monitoring. 4. Patients with GCS 5-12.
Exclusion criteria
Exclusion criteria: 1. Patients with open craniocerebral injury; 2. Patients with severe multiple organ injury (Abbreviated Injury Score > 3); 3. Patients with hypertensive disease; 4. Patients with intracranial pathological changes before their injury; 5. Patients with isolate traumatic epidural hemorrhage, brain stem contusion, cerebellar contusion/ hemorrhage 6. Patients with known organ disorders, such as coronary heart disease, renal failure, liver dysfunction and so on. 7. Patients taking anticoagulant therapies that could result in coagulopathies.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| The percentage of optimal CPP; | — |
Primary
| Measure | Time frame |
|---|---|
| GOSE; | — |
Countries
China
Contacts
Public ContactHengli Tian
Shanghai Jiaotong University Affiliated Sixth People's Hospital
Outcome results
None listed