Drug-induced liver injury
Conditions
Interventions
Sponsors
Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Those who meet the diagnostic criteria for tuberculosis and have abnormal liver function after applying anti-tuberculosis drugs; 2. The severity of DILI is graded 1-2; 3. The age range is between 18-75 years old; 4. Not taking other drugs to protect liver and reduce enzyme, Or has been suspended for more than 2 weeks; 5. Signed informed consent voluntarily.
Exclusion criteria
Exclusion criteria: 1. The liver function test before medication is elevated in alanine aminotransferase or bilirubin, and any of them is> 2 times the upper limit of normal value; 2. People with HIV infection, the original history of viral hepatitis or serological signs of hepatitis Those with positive substance; 3. Combined with serious primary diseases such as cardiocerebrovascular, kidney, hematopoietic system, peptic ulcer, or serious diseases (such as tumors) that affect their survival, or patients with mental or legal disabilities; 4. Do have a history of alcohol and drug abuse; 5. Allergic constitution, or known to be allergic to the drug components in the test protocol; 6. Pregnant, pregnant or lactating women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Liver function;TCM syndrome points;Life quality assessment; | — |
Secondary
| Measure | Time frame |
|---|---|
| Immune function test;Coagulation test;Renal function; | — |
Countries
China
Contacts
Public ContactFeng Jiang
Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine
Outcome results
None listed