Tracheal intubation
Conditions
Interventions
Mica?:intubation after mivacurium injection
Rocu?:intubation after rocuronium injection
Sponsors
Department of Anesthesiology, Zhongshan Hospital, Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients undergoing elective operation under general anesthesia with tracheal intubation; 2. Patients aged 18-65 years; 3. The American Society of anesthesiologists (ASA) was graded I-II; 4. Patients with malampati airway grade I-II; 5. Patients willing to sign informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with severe respiratory diseases, COPD, asthma and airway hyperresponsiveness; 2. Patients with severe cardiovascular diseases, such as coronary heart disease, severe valvular disease, etc; 3. Patients with abnormal liver and kidney function; 4. Patients with severe electrolyte imbalance; 5. Neuromuscular system diseases: patients who have used neuromuscular blockers within one week, and those who have recently used drugs that interfere with neuromuscular excitation conduction, such as antiepileptics, hormones, furosemide, aminoglycoside antibiotics, etc; 6. Objects with high risk of backflow and misabsorption; 7. Those who were previously allergic to micuronium, rocuronium or other muscle relaxants; 8. Patients with known plasma cholinesterase deficiency; 9. Pregnant or lactating women; 10. Patients who have participated in any drug clinical trials within 30 days before the start of the study; 11. Other conditions that the researchers think are not suitable for inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proportion of patients in each group with excellent or clinically acceptable intubation condition; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cormack-Lehane grade;Cooper's tracheal intubation scores;SBP, DBP, MAP, HR, SpO2 of each time point;time of intubation;time of RSI;attempt of intubation;Skin flushing, lung wheezing rale; | — |
Countries
China
Contacts
Public ContactXiaoguang Zhang
Zhongshan Hospital Affiliated to Fudan University
Outcome results
None listed