Parkinson's disease
Conditions
Interventions
Asleep DBS:General anesthesia during the surgery
Awake DBS:Awake during the surgery
Sponsors
Shenzhen Second People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Patients with primary Parkinson's disease with a course of more than 4 years; 2. The mds-updrs III score of acute levodopa shock test improved more than 30% in patients sensitive to levodopa treatment; 3. Patients with symptom fluctuation or dyskinesia; 4. Patients aged 18-75 years; 5. Patients with normal head MRI; 6. Patients with normal cognitive function (MMSE >= 26); 7. In medicine, sleeping or awake operation is safe; 8. Patients willing to sign informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with Parkinson's superposition syndrome; 2. Patients with previous history of craniocerebral surgery (including mutilation and gamma knife surgery); 3. Patients with serious metabolic diseases; 4. Patients with serious heart, lung, kidney or liver diseases; 5. Patients with serious mental illness; 6. Patients with severe depression, clinically uncontrolled severe depression (BDI > 20) 7. Patients with severe cognitive decline; 8. Brain MRI showed obvious atrophy; 9. Pregnant or lactating women; 10. Patients with a history of attempted suicide; 11. Patients with obesity or serious potential respiratory problems; 12. The nuclei other than STN target were excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative relief of disease in patients; | — |
Secondary
| Measure | Time frame |
|---|---|
| The change of levodopa equivalent dose, LED;the change of Neurocognitive Function;the change of Quality of life;Lead Placement;Stimulation Parameters;Operation Data;Stimulation related side effects; | — |
Countries
China
Contacts
Public ContactXiaodong Cai
Shenzhen Second People's Hospital
Outcome results
None listed