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Comparison of three non-invasive ventilation modes in the application of primary respiratory support for premature infants with respiratory distress: a randomized controlled trial.

Comparison of three non-invasive ventilation modes in the application of primary respiratory support for premature infants with respiratory distress

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2000032560
Enrollment
Unknown
Registered
2020-05-02
Start date
2020-06-01
Completion date
Unknown
Last updated
2020-05-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

RDS for preterm infants

Interventions

Group 1:SNIPPV
Group 2:NHFOV

Sponsors

The Affiliated Hospital of Traditional Chinese Medicine of Southwest Medical University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: (1) Gestational age < 37 weeks, birth weight < 2500g; (2) The clinical diagnosis is RDS, requiring ventilator assisted ventilation, and the first time after birth to receive respiratory support treatment; (3) Parents sign informed consent.

Exclusion criteria

Exclusion criteria: (1) Obvious congenital malformation or chromosomal diseases (such as complete cleft palate, trisomy syndrome, complicated congenital heart disease, etc.); (2) Neuromuscular diseases affecting respiratory function (congenital central hypoventilation syndrome, myasthenia gravis, etc.); (3) There are structural abnormalities of the respiratory tract (pierre-robin syndrome, congenital laryngeal softening, atresia of the nasal cavity, severe nasal injury, etc.); (4) There are surgical diseases requiring surgical treatment (diaphragmatic hernia, congenital tracheoesophageal fistula, digestive tract malformation, complex congenital heart disease, etc., but not including PDA ligation after inclusion, NEC surgical treatment).

Design outcomes

Primary

MeasureTime frame
Incidence of Intrusive mechanical ventilation;Incidence of BPD;

Secondary

MeasureTime frame
PDA;ROP;IVH;NEC;Total length of hospital stay;Mortality;

Countries

China

Contacts

Public ContactYuanxia Zou

The Affiliated Hospital of Traditional Chinese Medicine of Southwest Medical University

1406708269@qq.com+86 17380858341

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026