Post Stroke Cognitive Impairment
Conditions
Interventions
experimental group:Routine treatment and butylphthalide 200mg t.i.d
control group:Routine treatment
Sponsors
The First Affiliated Hospital of Xi'an Jiaotong University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients aged 50-75 (including 50 and 75 years old) years, regardless of gender; 2. Patients who meet the diagnostic criteria of acute cerebral infarction in cerebrovascular disease group of Chinese Medical Association; 3. Patients with acute cerebral infarction supported by cranial MRI; 4. Patients with unconsciousness, obvious aphasia and severe limb paralysis who can complete the cognitive scale; 5. Subjects with primary school education and above who are able to complete cognitive function assessment; 6. The patient and his / her family members agree and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients with acute cerebral infarction treated by intravenous or arterial thrombolysis or emergency intravascular intervention; 2. Patients with cerebral infarction secondary hemorrhage and hematoma; 3. Patients with cognitive impairment before cerebral infarction; 4. Patients with nervous system diseases, including neurodegenerative diseases (Alzheimer's disease, Parkinson's; disease, Lewy body dementia, frontotemporal dementia, etc.), optic neuritis, epilepsy, central nervous system infection (such as AIDS, syphilis, etc.), brain traumatic dementia, etc; 5. Psychotic patients, according to DSM-IV-TR standard, including schizophrenia or other mental diseases, bipolar disorder, major depression or delirium; 6. Patients who are using cholinesterase inhibitors, memantine or butylphthalide; 7. Patients with uncorrectable visual and auditory disorders who can not complete neuropsychological test and scale evaluation; 8. Patients with unstable or serious heart, lung, liver, kidney and hematopoietic system diseases; 9. Patients who can not be examined by MRI; 10. Patients who could not be followed up as required during the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| magnetic resonance imaging;Cognitive and psychosomatic correlation scales; | — |
Secondary
| Measure | Time frame |
|---|---|
| Plasma inflammatory factor; | — |
Countries
China
Contacts
Public ContactQu Qiumin
The First Affiliated Hospital of Xi'an Jiaotong University
Outcome results
None listed