Major Depressive Disorder
Conditions
Interventions
SSRIs-treated group:Treat with the combination of SSRIs (sertraline or escitalopram) in the first 6 weeks.Those whose efficacy is well in the first stage of treatment will continue to receive the orig
Agomelatine-treated group:Treat with Agomelatine in the first 6 weeks.Those whose efficacy is well in the first stage of treatment will continue to receive the original drug and the same dose.Others w
Sponsors
Shandong Mental Health Center
Eligibility
Sex/Gender
All
Age
25 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1.Meet the diagnostic criteria for DSM-5 'major depressive disorder' ; 2.Patients with first episode of major depressive disorder who have not received any treatment, or have not received any treatment in the last 2 months; 3.Aged of first onset >= 25 years; 4.Han nationality, 25-60 years old, regardless of gender; 5.Hamilton Depression Scale (HAMD-17) >=17, Hypomania Check List(HCL-32) <13; 6.Junior high school or above; 7.Participate in this study voluntarily and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1.A history of serious physical diseases, organic brain diseases and craniocerebral trauma; 2.Patients with severe mental retardation; 3.Hepatitis B virus carriers / patients, Hepatitis C virus carriers / patients, or those with transaminase exceeding the normal upper limit; 4.Patients who abuse drugs, alcohol or other psychoactive substances; 5.Persons known to be allergic to the ingredients of research drugs; 6.Family history of bipolar disorder; 7.Those who are currently in the perinatal period or have a pregnancy plan.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hamilton Depression Scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hamilton Anxiety Scale;Snaith-Hamilton Pleasure Scale;Thinc-it;Hypomania Check List; | — |
Countries
China
Contacts
Public ContactGuanglei Xun
Shandong Mental Health Center
Outcome results
None listed