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A 24-Month Randomized Controlled Study on Treatment of Orthodontic Cretaceous Spots With Resin Infiltration, CPP-ACP and Sodium Fluoride Coating

A 24-Month Randomized Controlled Study on Treatment of Orthodontic Cretaceous Spots With Resin Infiltration, CPP-ACP and Sodium Fluoride Coating

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2000032516
Enrollment
Unknown
Registered
2020-05-01
Start date
2020-05-06
Completion date
Unknown
Last updated
2020-05-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

white spot lesion on teeth

Interventions

1:CPP-ACP
2:duraphat
3:resin infiltration
4:placebo

Sponsors

The Affiliated Hospital of Stomatology, Sun Yat-Sen University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
14 Years to 20 Years

Inclusion criteria

Inclusion criteria: (1) Male and female aged 14-20 years; (2) participation in a 24-month clinical trial study; (3) good general health; (4) two or more wsls on the buccal surface of the anterior teeth, with visible visual changes in enamel and/or local enamel rupture and no clinical visual indications involving dentin [International Caries Detection and Assessment System (icdas) Code 2/3]; (5) signature of an informed consent.

Exclusion criteria

Exclusion criteria: (1) a history of antibiotic use within one month prior to entering the trial; (2) a pregnant or lactating woman; (3) a smoker; (4) a patient with systemic disease or syndrome; (5) a proven or suspected allergy to fluoride or milk protein and/or sensitivity to benzoic acid preservatives (ingredients of the cpp-acp product).

Design outcomes

Primary

MeasureTime frame
Change in wsl area;—

Countries

China

Contacts

Public ContactZhi Qinghui

The Affiliated Hospital of Stomatology, Sun Yat-Sen University

zhiqinghui@qq.com+86 13660093543

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Jun 1, 2026