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Intraoperative allogeneic blood transfusion is involved in regulating Tregs differentiation through TGF - ß / Smad pathway, and then affects transfusion related immune regulation in children with malignant tumors

Intraoperative allogeneic blood transfusion is involved in regulating Tregs differentiation through TGF - ß / Smad pathway, and then affects transfusion related immune regulation in children with malignant tumors

Status
Recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2000032515
Enrollment
Unknown
Registered
2020-05-01
Start date
2020-04-27
Completion date
Unknown
Last updated
2020-05-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Malignant tumor in children

Interventions

case series:N/A

Sponsors

Guangzhou Women and Children's Medical Centre
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Children who choose to undergo intracranial or mediastinaltumor surgery in Guangzhou Women's and children's Medical Center, regardless of gender. Inclusion criteria: aged < 16 years.

Exclusion criteria

Exclusion criteria: Known severe liver disease, known bleeding diathesis, immunosuppressive disease, chemotherapy or long-term corticosteroid treatment.

Design outcomes

Primary

MeasureTime frame
Treg cell number and function;—

Secondary

MeasureTime frame
CD4+T/Treg,CD8+T/CD4Treg/Treg/Th17;Expression of related genes;Changes of main immune factors;—

Countries

China

Contacts

Public ContactNa Zhang

Guangzhou Women and Children's Medical Centre

na999666@163.com+86 13560409867

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026