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Study for the central mechanism of knee osteoarthritis pain based on multimodal MRI

Study for the central mechanism of knee osteoarthritis pain based on multimodal MRI

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2000032489
Enrollment
Unknown
Registered
2020-04-29
Start date
2020-04-30
Completion date
Unknown
Last updated
2020-05-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Knee Osteoarthritis

Interventions

Health Group:No

Sponsors

Shanghai Guanghua integrated traditional Chinese and Western Medicine Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
50 Years to 70 Years

Inclusion criteria

Inclusion criteria: Inclusion criteria of patients with knee osteoarthritis 1. Aged 50-70 years old; 2. It was diagnosed as osteoarthritis of knee joint and agreed to participate in the experiment; 3. All of them are right handed; 4. KL Level 2 or 3; 5. The pain time of knee joint is more than or equal to 3 months; 6. Agree and sign the informed consent. Inclusion criteria for healthy volunteers 1. Right handedness; 2. aged 50-70 years old; 3. No history of chronic pain; 4. In the past 1 month, he did not receive medication, physical therapy or massage therapy; 5. Understand the process of the study, agree and sign the informed consent.

Exclusion criteria

Exclusion criteria: Exclusion criteria 1. Patients taking analgesics or anti-inflammatory analgesics within the past 1 month; 2. Patients who received any other treatment within the past month; 3. Pregnant or lactating women; 4. Patients with mental disease, neurological disease, infectious disease, gastrointestinal disease, cardiovascular and cerebrovascular disease, immunologic disease, respiratory disease or kidney disease; 5. Patients with tumor, tuberculosis, rheumatism or rheumatoid arthritis, gout, joint trauma, or any other chronic pain symptoms, or with a history of brain injury with loss of consciousness; 6. Patients with MRI contraindications such as atresia phobia, pacemaker, defibrillator, cardiac stent, intrauterine device, etc.

Design outcomes

Primary

MeasureTime frame
MRI scan to obtain various modal parameters;

Countries

China

Contacts

Public ContactXiao Lianbo

Shanghai Guanghua integrated traditional Chinese and Western Medicine Hospital

xiao_lianbo@163.com+86 13849429347

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026