postoperative immune function and stress hormones in patients with breast cancer surgery
Conditions
Interventions
GA group:general anaesthesia
ESPB group:general anaesthesia combined with erector spinae plane block
Sponsors
Department of Anesthesiology, Shenzhen Second People's Hospital
Eligibility
Sex/Gender
Female
Age
20 Years to 70 Years
Inclusion criteria
Inclusion criteria: Eighty female patients undergoing elective unilateral radical mastectomy under general anesthesia, aged 18~80 years, ASAI~II, BMI <= 30kg/m2 are going to be enrolled.All the patients are diagnosed as breast cancer by histopathological examination, and the surgical method are unilateral modified radical mastectomy for breast cancer.
Exclusion criteria
Exclusion criteria: (1) coagulation dysfunction, puncture site infection, anatomical abnormality, anaesthetic drug allergy and other conditions that are not suitable for nerve block; (2) history of chronic pain and mental illness, and history of long-term opioid use; (3) patients with severe dysfunction of heart, liver and kidney; (4) other malignant tumors; (5) application of immunosuppressive agents.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| cortisol;prolactin;grouth hormone;Classification of peripheral blood lymphocytes; | — |
Secondary
| Measure | Time frame |
|---|---|
| visual analogue scale;press times of patient control analgesia;consumption of anaesthetic drugs;Postoperative circulation status;postoperative hospital stay; | — |
Countries
China
Contacts
Public ContactLiu Zhi-heng
Department of Anesthesiology, Shenzhen Second People's Hospital
Outcome results
None listed