Severe Acute Pancreatitis
Conditions
Interventions
Placebo group:Conventional therapy+Placebo (drug B1 1 needle qd. iv. 3days + drug B2 1 tablet bid. po. 27 days)
COX-2 inhibitors group:Conventional therapy+COX-2 inhibitors (drug A1-Parecoxib 1 needle qd. iv. 3days + drug B2- Imrecoxib 1 tablet bid. po. 27 days)
Sponsors
Department of Gastroenterology, West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Confirmed diagnosis of AP requiring two of the following three features: 1) Abdominal pain consistent with AP (acute onset of a persistent, severe, epigastric pain often radiating to the back); 2) Serum lipase activity (or amylase activity) at least three times greater than the upper limit of normal; 3) Characteristic findings of AP on computed tomography (CT) and less commonly magnetic resonance imaging (MRI) or abdominal ultrasonography; 2. Inpatients aged 18-75 years; 3. Onset of symptoms to admission no more than 1 week; 4. APACHE II score >= 7 or modified Marshall score >= 2;
Exclusion criteria
Exclusion criteria: 1. The use of non-steroidal anti-inflammatory drugs or glucocorticoids within 2 weeks prior enrollment; 2. Known allergy to sulfonamide drugs; 3. Pregnancy and lactation; 4. Presence of severe chronic diseases, such as cardiac dysfunction, chronic obstructive pulmonary disease, or renal insufficiency; 5. Severe digestive system diseases, such as liver cirrhosis, peptic ulcer with a history of gastrointestinal bleeding in the past month, chronic pancreatitis, and inflammatory bowel disease; 6. Drug abuse and psychosis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Duration of organ failure; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pancreatic necrosis;Presences of local complications;The use of mechanical ventilation or CRRT;Response to anti-infection treatment;Systemic inflammatory response syndrome score;ICU transfers;30-day mortality;The duration of hospital stay;The cost during hospitalization;Serum inflammatory markers;Others; | — |
Countries
China
Contacts
Public ContactChengwei Tang
Department of Gastroenterology, West China Hospital, Sichuan University
Outcome results
None listed