Effects of tranexamic acid on intestinal barrier protection in patients undergoing trauma: a randomized controlled trial

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2000032407

Enrollment

Unknown

Registered

2020-04-27

Start date

2020-05-01

Completion date

Unknown

Last updated

2020-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

trauma

Interventions

TXA group:Since the patient was admitted to the hospital, 1g of tranexamic acid was intravenously infused once every eight hours for three days

Control group:Nil

Eligibility

Sex/Gender

All

Age

18 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1. Aged between 18-70 years old; 2. ISS score >16; 3. Surgery treatment in our center due to abdominal trauma; 4.Informed consent, voluntary participation.

Exclusion criteria

Exclusion criteria: 1. Patients with fibrinolytic shutdown; 2. Pregnant patients.

Design outcomes

Primary

Measure	Time frame
Serum level of IL-10, IL-6, IL-10, TNF-alpha;Serum level of cf-DNA, CitH3;Thromboelastography;Tight junction proteins;The level of IL-10, IL-6, IL-10, TNF-alpha in intestine;The level of CitH3, MPO, NE in intestine;Intestinal histopathological scores;ISS score;	—

Secondary

Measure	Time frame
Coagulation index;Blood routine examination;	—

Countries

China

Contacts

Public ContactWeiwei Ding

Jinling Hospital, Medical School of Nanjing University

dingwei_nju@hotmail.com+86 15261897996

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026