chronic thromboembolic pulmonary hypertension
Conditions
Interventions
Riociguat Group:Riociguat
Riociguat+BPA Group:Riociguat and BPA
Sponsors
Shanghai Pulmonary Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: (1) Over 18 years old; (2) Right cardiac catheter: mean pulmonary artery pressure (mPAP) >= 25 mm Hg, pulmonary arteriole pressure (PAWP) >= 15 mm Hg and pulmonary vascular resistance (PVR) >= 3 wood units (240 dyn·s·CM-5); (3) CTPA or pulmonary ventilation perfusion imaging or pulmonary arteriography confirmed the presence of pulmonary embolism; (4) Patients with non central CTEPH are not suitable for pulmonary endarterectomy (PEA), or they refuse to do pea, or they are in poor condition and cannot tolerate pea; (5) CTEPH patients with who cardiac function grade II or above; (6) Sign written informed consent.
Exclusion criteria
Exclusion criteria: (1) Other types of pulmonary hypertension; (2) The patient refused to sign the informed consent or could not cooperate with the investigator during the trial; (3) Patients or their families refused to undergo balloon pulmonary angioplasty; (4) Patients with contraindications to the use of lyoxygenase; (5) Patients who used other pulmonary hypertension targeting drugs, drugs that could not be used with riociguat, and drugs that affected the blood concentration of riociguat; (6) Severe chronic or acute diseases of liver, kidney or central nervous system; (7) With unstable angina, or with a history of myocardial infarction, stroke or life-threatening arrhythmia within 6 months before the trial; (8) Patients who cannot lie on the operating table for a long time due to mental factors; (9) Patients in acute infection stage; (10) Active hemoptysis patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pulmonary vascular resistance; | — |
Secondary
| Measure | Time frame |
|---|---|
| mean pulmonary artery pressure;Cardiac output;6-minute walking distance;WHO-FC;Quality of life score;NT-proBNP;TAPSE;Area of right atrium;Eccentricity index;pericardial effusion; | — |
Countries
China
Contacts
Public ContactWang Lan
Shanghai Pulmonary Hospital
Outcome results
None listed