healthy donors for allogeneic hematopoietic stem cell transplantation
Conditions
Interventions
PEG-rhG-CSF group:PEG-rhG-CSF 12mg d1
rhG-CSF group:rhG-CSF 10ug/kg d1-d4
Sponsors
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1) Aged 14-60 years old; 2) Gender: male or female; 3) relationship between allogeneic hematopoietic stem cell transplantation of healthy donors; 4) Weight >=40kg; 5) General condition is acceptable, ECOG score=50%; 7) Normal liver and kidney function: serum bilirubin <=35umol/L, AST / ALT is below twice the upper limit of normal value, serum creatinine <=130 umol/L; 8) The subject signs the informed consent.
Exclusion criteria
Exclusion criteria: 1. unrelated allogeneic hematopoietic stem cell transplantation 2. ECOG score> 2; 3. Uncontrolled active infection; 4. Patients with renal insufficiency (creatinine >=176.8lmol/l); 5. Liver insufficiency (total bilirubin> 34.2 umol/L, ALT, AST>=3 times the upper limit of normal); 6. Patients with cardiac insufficiency (LVEF 12.95 mmol/l or triglyceride>5.65 mmol/l and the HIV antibody positive; 8. Pregnant or breastfeeding women; 9. Infected with human immunodeficiency virus (HIV); 10. Other situations that do not meet the enrolled criteria.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| CD34+ cell counts;mononuclear cell counts;collection times;adverse effect; | — |
Secondary
| Measure | Time frame |
|---|---|
| T cell subgroup;B cell subgroup;ratio of MDSC;expense of collection;non-relapsed mortality;transplantation related mortal;the ratio of GVHD;overall survival;disease free survival;the ratio of infection;leukocyte engraftment time;platele engraftment time; | — |
Countries
China
Contacts
Public ContactYicheng Zhang
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Outcome results
None listed