gynecological laparoscopic surgery
Conditions
Interventions
Control group:During induction, intravenous injection of saline. There is no esketamine in postoperative analgesia pump, and is replaced with an equal amount of normal saline. No difference in appeara
EK1:During induction, intravenous injection of 0.25 mg / ml esketamine. There is no esketamine in postoperative analgesia pump, and is replaced with an equal amount of normal saline.
EK2:During induction, intravenous injection of normal saline. There is 0.5mg/kg esketamine in postoperative analgesia pump.
EK3:During induction, intravenous injection of 0.25 mg / ml esketamine. There is 0.5mg/kg esketamine in postoperative analgesia pump.
Sponsors
The First Affiliated Hospital of Zhengzhou University
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1) The patient is between 18 and 60 years old; 2) Patients undergoing elective gynecological laparoscopic surgery; 3) ASA grade I or II; 4) 18.0 kg / m2 <= BMI<= 30.0 kg / m2.
Exclusion criteria
Exclusion criteria: 1) Patients who refuse to participate or those who should not participate in this trial; 2) Those allergic to esketamine, propofol or ropivacaine; 3) In the past, there were contraindications to the use of ketamine such as severe refractory hypertension, pulmonary heart disease, hyperthyroidism, epilepsy, increased intraocular pressure, increased intracranial pressure, or intracranial space occupying lesions, and a history of cerebrovascular accidents; 4) Patients with obstructive sleep apnea hypopnea syndrome or BMI> 30 kg / m2 or respiratory difficulties; 5) A history of alcoholism or taking psychotropic drugs or analgesic drugs within 24 hours before surgery; 6) Have a history of chronic pain; 7) During pregnancy or lactation; 8) Seizures; 9) Use drugs that affect the central nervous system; 10) Previous mental illnesses such as history of severe depression and mental illness.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Anesthesia recovery time;Dosage of opioids;Dosage of opioids;Hemodynamic indicators: such as blood pressure and heart rate;NRS score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative analgesic consumption;Postoperative adverse reactions: such as nausea and vomiting, respiratory depression, phantom vision, etc.; | — |
Countries
China
Contacts
Public ContactDan Cheng
The First Affiliated Hospital of Zhengzhou University
Outcome results
None listed