Secondary Hyperparathyroidism, SHPT
Conditions
Interventions
Case series:Paricalcitol
Sponsors
The First Affiliated Hospital of Shenzhen University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Ckd5d patients who received maintenance dialysis for at least 3 months, 3 times a week, single kt / V > 1.2; 2. First treatment patients: never received VitD and similar treatment; 3. Treated patients: they are being treated with VitD and its analogues, and PTH level is continuously higher than 300pg / ml, or it has a continuous upward trend in the past three tests; 4. Patients older than 18 years old; 5. Patients with baseline blood calcium less than 10.0 mg / dl (2.5 mmol / L).
Exclusion criteria
Exclusion criteria: 1. Patients whose serum level of iPTH was more than 1500pg / ml in the last two consecutive tests; 2. Allergic reaction to VD and its analogues; 3. Patients who received parathyroidectomy within one year; 4. Patients with indications for parathyroidectomy: (1) Patients with severe SHPT were resistant to active VD and its analogues; (2) Persistent hypercalcemia and / or hyperphosphatemia with ineffective drug treatment; (3) There is imaging evidence of at least one hyperparathyroidism. For example, high frequency color ultrasound shows that the diameter of the hyperparathyroidism is larger than 1cm and there is abundant blood flow; 5. Patients with severe infection; 6. Patients with malignant tumor; 7. Patients with a history of alcohol or drug abuse in the past 6 months; 8. Pregnant patients; 9. Patients with severe liver disease or liver dysfunction; 10. Patients who are allergic to or intolerable to any therapeutic drug; 11. Patients who were still participating in clinical studies of other drugs / devices 4 weeks before enrollment; 12. The researchers think that patients are not suitable to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hb;iPTH;Ca;P;CRP;IL-1;IL-6;IL-8;IL-10;TNF-alpha;IFN-gama;AP; | — |
Secondary
| Measure | Time frame |
|---|---|
| Heart valve calcification score;Diameter of parathyroid gland; | — |
Countries
China
Contacts
Public ContactQijun Wan
The First Affiliated Hospital of Shenzhen University
Outcome results
None listed