Acute myeloid leukemia
Conditions
Interventions
Case series:GHA+AZA regimen
Sponsors
The First Affiliated Hospital of Zhejiang University Medical College
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Primary acute myeloid leukemia patients, and written informed consents were obtained from patients or family members; 2. The newly diagnosed AML patients (except M3) were classified by WHO classification standard, including AML transformed from MDS; 3. Patients over 65 years old or 60-65 years old with complications or poor physical condition; 4. At the time of selection, the ECoG score of patients over 65 years old was 0-2, and that of patients over 60-65 years old was 2-4.
Exclusion criteria
Exclusion criteria: 1. Systemic or local treatment including chemotherapy within three weeks before admission; 2. Patients over 65 years old: liver and kidney function: bilirubin>2mg/dl (35 umol/L), AST/ALT more than twice the upper limit of normal value, creatinine>177µmol/L, creatinine clearance rate<60ml/min; 3. Abnormal cardiac function EF<=50%; 4. Expected survival <3 months; 5. Chronic or current active infectious diseases requiring systemic antibiotics, antifungal drugs or antiviral treatment; 6. Other concurrent and uncontrolled subjects believed to affect the medical status of patients participating in the study. Psychiatric patients or other patients who are known or suspected to be unable to fully comply with the protocol; 7. Patients with HIV.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Complete remission rate;Complete remission with incomplete blood recovery rate;Partial remission rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Overall survial duration;Relapse-free survial duration; | — |
Countries
China
Contacts
Public ContactJie Jin
The First Affiliated Hospital of Zhejiang University Medical College
Outcome results
None listed