ACL reconstruction
Conditions
Interventions
A:A traditional NSAID
B:a selective COX-2 inhibitor (celecoxib, Celebrex 100 mg twice a day
C:an opioid drug (tramadol)
D:Pregabalin
Sponsors
Department of Orthopaedic Surgery, West China Hospital of Sichuan University, Sichuan University
Eligibility
Sex/Gender
All
Age
16 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. ACL reconstruction is needed in patients with rupture of anterior cruciate ligament; 2. Patients with normal platelet and coagulation function before operation; 3. Those patients who had no abnormality in color Doppler ultrasonography of the veins of both lower limbs before operation; 4. Patients who voluntarily participate in the clinical trial and sign the informed consent and have good compliance.
Exclusion criteria
Exclusion criteria: 1. Patients with uncontrolled systemic infection such as pulmonary infection and urinary tract infection before operation; 2. Patients with abnormal immune function or immune related diseases before operation; 3. Patients with abnormal preoperative inflammatory index (CRP > 20 mg / L); 4. Patients with abnormal preoperative fibrinolysis index (FDP > 5 mg / L); 5. Patients who took anticoagulants or aspirin for less than 1 week; 6. Patients who are allergic to carbamic acid or dexamethasone or who are contraindicated; 7. Patients at high risk of thrombosis, including AF, pacemaker and stent implantation; 8. Patients with history of venous thromboembolism, pulmonary embolism, cerebral infarction and coronary heart disease; 9. Patients with severe hepatorenal insufficiency.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| VAS pain score;Healing; | — |
Secondary
| Measure | Time frame |
|---|---|
| Quadriceps muscle strength;Walking distance;Range of motion;PONV;color Doppler Ultrasonic (CDU) examination in lower extremity;IKDC;Lysholm;Satisfaction scores;Sleep quality;Opioid-Related Adverse Effects; | — |
Countries
China
Contacts
Public ContactJian Li
West China Hospital, Sichuan University
Outcome results
None listed