Anesthesia observation of single upper limb / clavicle fracture operation
Conditions
Interventions
Placebo group:intravenous placebo (normal saline)
low-dose nalmefene group :Intravenous low-dose of nalmefene
medium-dose nalmefene group:Intravenous medium-dose of nalmefene
high-dose nalmefene group :Intravenous high-dose of nalmefene
Sponsors
Funing People's Hospital of Jiangsu Province
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. 240 patients with single upper limb / clavicle fracture were selected for selective operation; 2. Patients with single and single fracture, excluding comminuted fracture, and having little difficulty in preoperative evaluation; 3. Patients with gender unlimited, ASA grade I-II, age 20-70, body mass index (BMI) 20-29kg / ?; 4. The patients who have no basic diseases of cardiopulmonary system and no history of disease attack, such as bronchospasm, asthma, etc; 5. Patients with normal intelligence, ability to understand and willing to participate in this study, and willing to sign informed consent.
Exclusion criteria
Exclusion criteria: 1. Pregnant and lactating women; 2. Patients with a long history of painful diseases; 3. Patients with allergic history of opioids or their antagonists; 4. Patients with a history of drug or alcohol dependence; 5. Patients with severe cardiopulmonary function, liver and kidney dysfunction; 6. Patients with severe snoring and obesity (BMI > 30 kg / m2); 7. Patients with history of digestive system diseases; 8. Patients with hypertension, diabetes, mental disorders and mental disorders.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Visual Analogue Scale/Score;Blood concentration;bispectral index,BIS;Vital signs;OAA/S Score;Anesthesia induction observation;Anesthesia maintenance observation;Anesthesia recovery observation; | — |
Countries
China
Contacts
Public ContactDekun Yin
Funing People's Hospital of Jiangsu Province
Outcome results
None listed