Novel Coronavirus Pneumonia (COVID-19)
Conditions
Interventions
mechanic ventilation:mechanic ventilation
Sponsors
Bayi Children's Hospital, Seventh Medical Centre, PLA General Hospital
Eligibility
Sex/Gender
All
Age
No minimum to 100 Years
Inclusion criteria
Inclusion criteria: 1. confirmed SARS-CoV-2 infection; 2. Meet one of the following criteria: 1) reversible respiratory failure with hypoxemia (partial pressure of arterial oxygen (PaO2 ) to the fraction of inspired oxygen (FiO2 ) ratio less than 50 mmHg for more than 3 hours and/or PaO2/FiO2 ratio less than 80 mmHg for more than 6 hours; 2) Arterial blood pH less than 7.25 with a partial pressure of arterial carbon dioxide (PaCO2) of at least 60 mmHg for more than 6 hours with respiratory rate more than 35 breaths per minute; 3) Plateau pressure more than 30-35 cmH2O despite optimization of mechanical ventilation.
Exclusion criteria
Exclusion criteria: 1. mechanical ventilation at high settings (FiO2>0.9, P-plat>30) for>=7days; 2. recent central nervous system hemorrhage; 3. existence of non-recoverable terminal disease.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| in-hospital mortality; | — |
Secondary
| Measure | Time frame |
|---|---|
| cause of death;hemoglobin;WBCs;Serum creatinine;serum total bilirubin;PH;PaCO2;PaO2;lactic acid;troponin;CK-MB; | — |
Countries
China
Contacts
Public ContactFeng Zhichun
Seventh Medical Center of PLA General Hospital
Outcome results
None listed