Chronic hepatitis B, cirrhosis, non-alcoholic fatty liver disease, hepatocellular carcinoma, autoimmune liver disease
Conditions
Interventions
CHB:No intervention
LC:No intervention
HCC:No intervention
AIH:No intervention
Sponsors
Liver Disease Center of Xiamen Traditional Chinese Medicine Hospital
Eligibility
Sex/Gender
Male
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) Chronic hepatitis B: 1) The age is between 18-75 years old, regardless of gender; 2) CHB patients who meet the diagnostic criteria of the "Chronic Hepatitis B Prevention and Treatment Guidelines (2015 Edition)", have indications for antiviral therapy and have not been treated, or CHB patients with HBV DNA 1.5ULN or liver biopsy confirmed as NASH; 4) Patients taking antihypertensive drugs require blood pressure to remain stable (= 1:40 is 1 point, ANA, ASMA >= 1: 80 or LKM >= 1: 40 or SLA antibody positive 2 points; 2) IgG> 1.1ULN is 2 points; 3) Liver pathology suggests a typical AIH of 2 points and a combined AIH of 1 point; 4) 2 points without viral hepatitis. The total score is >= 7 points to confirm the diagnosis, and >= 6 points to the suspicious AIH. (5) Liver cancer 1) Age 18-75 years old; 2) Patients with primary advanced liver cancer who failed to receive sorafenib treatment in the first line; 3) Estimated survival time >= 3 months; 4) The tumor accounts for less than 70% of the entire liver; the main portal vein is not completely obstructed, or although the obstruction is complete but the portal vein is rich in compensatory collateral vessels, or hepatic cancer can be re-opened through the portal vein stent.
Exclusion criteria
Exclusion criteria: (1) Chronic hepatitis B 1) For those who are allergic to IFN a and its pharmaceutical ingredients, the investigator judges that the patient is not suitable for the application of IFN a; 2) Combined with HAV, HCV, HDV, HEV, HIV infection, or combined with alcoholic liver disease, genetic metabolic liver disease, drug-induced liver disease, non-alcoholic fatty liver disease and other chronic liver diseases; 3) Combining autoimmune diseases, including autoimmune liver diseases and psoriasis; 4) Neutrophil count 200ng / ml, creatinine> 1.5 x UNL, chronic liver failure or chronic acute liver failure, Child-Pugh score greater than 12 points, combined with severe mental illness and other important organs Device failure, pregnant women and lactating women, patients with poor compliance and unable to complete follow-up requirements. (3) Non-alcoholic fatty liver disease 1) In the past 5 years, there has been alcohol and / or drug abuse and dependence; 2) The average daily alcohol intake of women in the past was > 10g / day, and the average daily alcohol intake of men was> 20g / day; 3) Combining other acute and chronic active liver diseases (viral hepatitis, hereditary hemochromatosis, hepatolenticular degeneration, alpha-antitrypsin deficiency, alcoholic liver disease, drug-related liver disease); 4) Patients with cirrhosis; 5) Cardiac insufficiency, the heart function grade is 2, 3 or 4; 6) Patients with cardiac pacemakers; 7) Uncontrollable hypertension; 8) Renal insufficiency, blood creatinine> upper limit of normal; 9) Pregnant or lactating women; 10) Women who have a positive early pregnancy screening test or who do not want to use contraception during the observation period; 11) People with HIV infection; 12) Those who cannot accept MRI examination; 13) Long-term use of antibiotics (> 1 week); 14) Uncontrolled hypothyroidism (TSH> 2 times the upper limit of normal value); 15) Other researchers believe that the clinical trial cannot be completed; 16) Those who cannot sign the informed consent. (4) Autoimmune liver disease and primary biliary cholangitis 1) Drug-induced hepatitis; 2) Fatty hepatitis; 3) Viral hepatitis; 4) Combined with liver cancer; 5) Combining
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| CD33;CD11b;ALT;AST;GGT;TC;TCHO;AFP;HBV—DNA;HBsAg;HBeAg; | — |
Countries
China
Contacts
Public ContactHuiqing-Liang
Xiamen City Hospital of Traditional Chinese Medicine
Outcome results
None listed