B cell leukemia and lymhpoma, multiple myeloma, and ovarian cancer
Conditions
Interventions
5 groups:CART therapy
Sponsors
The Second Xiangya Hospital of Central South University
Eligibility
Sex/Gender
Male
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Voluntary to enroll with signed consent form; 2. Aged 18 to 65 years, the expected survival time is more than 3 months; 3. ECOG score =3.0x10^9/L, Lymphocyte count >0.5x10^9/L, PLT >=50x10^9/L (not including patients with leukemia and lymphoma); liver function: TBIL =55% 6. Female patient within childbearing age must use appropriate contraception during the study, and urea/blood pregnancy test must be negative before and during the study.
Exclusion criteria
Exclusion criteria: 1. Treated with CART therapy previously; 2. Pregnant or nursing female patients; 3. Remaining disease of other malignant tumors; 4. Patients with severe psychiatric disorders; 5. Patients with other serious diseases (such as autoimmune diseases, immune deficiency, organ transplantation) that conflict with this study; 6. Patients with allogeneic hematopoietic stem cell transplantation; 7. Patients with infectious or viral diseases (HIV positive, syphilis, hepatitis b or c, etc.); 8. Patients with severe allergic constitution; 9. Patients with severe heart, liver, renal insufficiency, diabetes and other diseases; 10. Patients who have participated in other clinical studies in the past 3 months or have previously received other gene product treatments.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Partial or complete remission; | — |
Countries
China
Contacts
Public ContactGuangshi Tao
The Second Xiangya Hospital of Central South University
Outcome results
None listed