schizophrenia
Conditions
Interventions
Sponsors
Chang'an Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Schizophrenia group: 1. Subject to consent by Ethics Committee of China Clinical Trial Registration Center , the guardian of all participants signed a written informed consent; 2. 100 cases from Chang'an Hospital must be in accordance with the DSM-5 schizophrenia or schizophreniform disorder diagnosis standards; the score of Positive and negative symptoms scale (PANSS) is greater than or equal to 60; Aged 18 to 65; 3. Did not use probiotics and probiotic fermented food within 1 mouth; 4. Did not use any antibiotics within 1 month. Depression group: 1. Subject to consent by Ethics Committee of China Clinical Trial Registration Center, all participants (or guardians) signed a written informed consent; 2. 100 cases from Chang'an Hospital must be in accordance with the DSM-5 major depressive disorder diagnosis standards; the score of HAMD is greater than or equal to 18; Aged 18 to 65 years; 3. Did not use probiotics and probiotic fermented food within 1 mouth; 4. Did not use any antibiotics within 1 month. Bipolar disorder group: 1. Subject to consent by Ethics Committee of China Clinical Trial Registration Center, all participants (or guardians) signed a written informed consent; 2. 100 cases from Chang'an Hospital must be in accordance with the DSM-5 bipolar disorder diagnosis standards (50 cases of depressive episodes, 50 cases of hypomania and manic episodes); HAMD score >= 18 points or YMRS score >= 20 points; Aged 18 to 65 years; 3. Did not use probiotics and probiotic fermented food within 1 mouth; 4. Did not use any antibiotics within 1 month.
Exclusion criteria
Exclusion criteria: Exclusion criteria 1. Patients with inflammatory bowel disease, crohn's disease or other diseases of the digestive system, patients with other organic diseases; 2. Obesity: BMI >= 28.0; hyperglycemia: FPG >= 6.1mmol/L and/or somebody has been diagnosed with diabetes and treatment; TG >= 2.3 mmol/L; hypertension: systolic >= 140mmHg or diastolic blood pressure >= 90mmHg; 3. Pregnant or lactating women; 4. Severely unbalanced diet, such as high-fat diet or long-term vegetarians; 5. Suffering from other mental disorders in line with DSM-5 diagnostic criteria;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fecal Sample Test;blood sample metabolomics;Hamilton depression scale;Young manic rating scale;positive and negative syndrome scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| Global Assessment Function; | — |
Countries
China
Contacts
Public ContactLin Guo
Chang'an Hospital
Outcome results
None listed