upper digestive tract disease
Conditions
Interventions
A group:0.5mg / kg esketamine combined with propofol / etomidate Mixture
B group:1mg / kg esketamine combined with propofol / etomidate Mixture
control group:propofol / etomidate Mixture
Group C (pediatric, middle-aged and elderly):propofol / etomidate Mixture
Group D (pediatric, middle-aged and elderly):esketamine combined with propofol / etomidate Mixture
Sponsors
Shunde Hospital of Southern Medical University (the First People's Hospital of Shunde)
Eligibility
Sex/Gender
All
Age
6 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1) Aged 6 to 85 years, regardless of gender; 2) Perform elective gastroscopy surgery; 3) ASA grade I or II; 4) 18.0 kg / m2 ? BMI ? 30.0 kg / m2.
Exclusion criteria
Exclusion criteria: 1) Patients who refuse to participate; 2) Those allergic to propofol, etomidate or esketamine; 3) Severe cardiovascular, lung, liver and kidney dysfunction or impaired adrenocortical function; 4) Patients with obstructive sleep apnea hypopnea syndrome or BMI > 30 kg / m2 or respiratory difficulties; 5) A history of alcoholism or taking psychotropic drugs or analgesic drugs within 24 hours before surgery; 6) Have a history of chronic pain; 7) During pregnancy or lactation; 8) Seizures; 9) Those with increased intracranial pressure or intraocular pressure; 10) Use drugs that affect the central nervous system; 11) Ischemic heart disease; 12) Psychological problems or history of mental illness; 13) History of hyperthyroidism.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| dose of Propofol/etomidate mixed;ED50 of propofol / etomidate Mixture; | — |
Secondary
| Measure | Time frame |
|---|---|
| Heart rate and blood pressure;breathing;Anesthesia recovery time;Satisfaction of endoscopy doctor and patient;Remedy situation; | — |
Countries
china
Contacts
Public ContactZhang Zhongqi
Shunde Hospital of Southern Medical University (the First People's Hospital of Shunde)
Outcome results
None listed