depression
Conditions
Interventions
female depression with childhood trauma group:N/A
female depression without childhood trauma group:N/A
Healthy control group:N/A
Sponsors
Department of Psychosomatics and Psychiatry, Zhongda Hospital, School of Medicine, Southeast University
Eligibility
Sex/Gender
Female
Age
20 Years to 40 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria for the patient group: 1) female; 2) meet the diagnostic criteria of MDD in DSM-IV; 3) 17-item Hamilton depression scale (HAMD-17) score >= 17; 4) aged from 20 to 40 years; 5) history of electroconvulsive therapy; 6) right-handedness. Inclusion criteria for the healthy control group: 1) healthy women with age and education level matching the patient group were selected, and the HAMD-17 rating was < 8 (and the "depression mood" score was 0); 2) no history of serious heart, brain or kidney disease, no history of alcohol or drug abuse, no family history of mental illness; 3) no pacemaker or metal material in the body, and no t2-weighted MRI showed cerebral infarction or other vascular injuries in patients who were able to receive MRI examination; 4) right-handedness.
Exclusion criteria
Exclusion criteria: 1) severe suicidal tendencies; 2) had taken mood stabilizers, antipsychotics, or any antidepressant for treatment or drugs that may affect the activity of the HPA axis within 2 weeks prior to enrollment; 3) the previous history of other mental illness; 4) obvious abnormality in laboratory and auxiliary examination; 5) those who fail to cooperate with the examination or cannot complete the examination due to consciousness impairment or visual, hearing, speech and understanding impairment; 6) patients with a primary brain tumor, metastatic brain cancer, brain trauma, multiple sclerosis or severe physical diseases (including severe cardiopulmonary, liver and kidney dysfunction, shock, malignant tumor or blood disease, and autoimmune diseases); 7) t2-weighted MRI showed cerebral infarction or other vascular injuries; 8) patients with a pacemaker or metal material in the body cannot be examined by MRI.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MRI index;peripheral protein index;clinical scales; | — |
Countries
China
Contacts
Public ContactYuan Yonggui
Zhongda Hospital, School of Medicine, Southeast University
Outcome results
None listed