cervical cancer
Conditions
Interventions
with brachytherapy boost group:with brachytherapy boost
without brachytherapy boost group:without brachytherapy boost group
Sponsors
Sun-Yat Sen Memorial Hospital, Sun-Yat Sen University
Eligibility
Sex/Gender
Female
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Patients with squamous-cell carcinoma or adenocarcinoma (according to WHO histological type) confirmed by operation; 2. Aged 18-70 years; 3. Tumor staged as I/IIA (according to the FIGO 2009 edition staging system); 4. Received a radical hysterectomy and lymphadenectomy; 5. No evidence of distant metastasis (M0); 6. Performance status: KPS > 70; 7. Adequate marrow, normal renal and liver function tese; 8. Written informed consent.
Exclusion criteria
Exclusion criteria: 1. WHO type non-squamous cell carcinoma or non-adenocarcinoma such as neurosecretory large/small cell carcinoma, and the sarcoma; 2. Patients with radical chemoradiotherapy; 3. Prior malignancy (except adequately treated carcinoma in-situ of the cervix or basal/squamous cell carcinoma of the skin); 4. Pregnancy or lactation (consider pregnancy test in women of child-bearing age and emphasize effective contraception during the treatment period); 5. History of previous RT (except for non-melanomatous skin cancers outside intended RT treatment volume); 6. Any severe intercurrent disease, which may bring unacceptable risk or affect the compliance of the trial, for example, unstable cardiac disease requiring treatment, renal disease, chronic hepatitis, diabetes with poor control (fasting plasma glucose > 1.5 x ULN), and emotional disturbance; 7. Previous hysterectomy with benign uterine lesions do not affect the enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 5-year local-regional recurrences free survival rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| 5-year overall survival;5-year disease-free survival; | — |
Countries
China
Contacts
Public ContactShoumin Bai
Sun-Yat Sen Memorial Hospital, Sun-Yat Sen University
Outcome results
None listed