Pancreatic cancer
Conditions
Interventions
Experimental group:Iodine-125 seed implantation plus chemotherapy
Control group:Chemotherapy
Sponsors
The Second Hospital of Shandong University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age: 18-80 years old, gender unlimited; 2. Patients with pancreatic cancer confirmed by histopathology; 3. Patients with locally advanced pancreatic cancer confirmed by imaging (enhanced CT / enhanced MR); 4. Patients without systemic metastasis; 5. Patients with expected survival time >=3 months; 6. Patients with ECoG score <=2; 7. Patients who did not receive radiotherapy, chemotherapy or molecular targeted therapy within one month before treatment; 8. Patients willing to participate in this study and sign informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with distant metastasis or other malignancies besides pancreatic cancer; 2. Patients with WBC count <=3.0x10^9/L; 3. Patients with platelet count <=50x10^9/L; 4. Patients with coagulation dysfunction; 5. Patients with serious diseases of heart, lung, brain, liver, kidney and other important organs; 6. Patients with mental disorder or mental history; 7. Patients with abnormal thyroid function; 8. Patients with acute or chronic infection; 9. The investigator confirmed that the patients are not suitable for the group.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Overall Survival; | — |
Secondary
| Measure | Time frame |
|---|---|
| PFS;ORR;DCR; | — |
Countries
China
Contacts
Public ContactYuliang Li
The Second Hospital of Shandong University
Outcome results
None listed