primary biliary cholangitis
Conditions
Interventions
Gold Standard:Any two of the following items met:
1. increased biochemical indicators of cholestasis such as alkaline phosphatase
2. positive serum AMA or AMA-M2
3. hepatic histopathology.
and 
ultrasound?transient 
(TE)
Sponsors
You'an Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Case group inclusion criteria: (1) Aged 18 to 70 years; (2) The diagnosis of PBC is confirmed by the result of liver biopsy, which include the stage of liver fibrosis; (3) The patient with cirrhosis due to PBC is diagnosised by clinical indicator according to consensus on the diagnosis and management of primary biliary cirrhosis (2015); 2. Control group inclusion criteria; (1) Aged 18 to 70 years, normal transaminase levels; no previous history of heart disease, lung disease, liver disease or cancer; and no history of long-term drug use or excessive alcohol consumption; (2) Definitive diagnosis of chronic hepatitis B (CHB) and chronic hepatitis C (CHC), patients with nonalcoholic fatty liver disease (NAFLD).
Exclusion criteria
Exclusion criteria: Patients with viral hepatitis, drug hepatitis, steatohepatitis, alcoholic hepatitis, metabolic liver disease and human immunodeficiency virus infection, pregnant or lactating women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The size of liver;The size of spleen;Hepatic stiffness;controlled attenuation parameter (CAP); | — |
Countries
China
Contacts
Public ContactYUAN ZHANG
You'an Hospital, Capital Medical University
Outcome results
None listed