gouty knee arthritis
Conditions
Interventions
B:Topical application of 1.5g/50mL TXA through drainage, and drain clamping for 3 h
C:Topical application of 3.0 g/50mL TXA through drainage, and drain clamping for 3 h
Sponsors
Department of Orthopaedic Surgery, West China Hospital, West China Medical School, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: (1) The patients with knee gouty arthritis undergoing arthroscopic arthrolysis; (2) Normal platelet and coagulation function preoperatively; (3) Normal intravenous ultrasound in the lower extremities preoperatively; (4) To be able to and willing to provide signed informed consent.
Exclusion criteria
Exclusion criteria: (1) Systemic infections such as pulmonary infection or urinary tract infection are not controlled preoperatively; (2) Abnormal immune function or combined immune-related disease preoperatively; (3) Abnormal inflammatory index preoperatively (C-reactive protein >20 mg/L); (4) Abnormal fibrinolysis index preoperatively (FDP > 5mg/L); (5) Discontinuation of oral anticoagulants or aspirin less than 1 week; (6) Allergy to tranexamic acid; (7) High-risk patients with thrombosis, including atrial fibrillation, pacemaker and stent implantation; (8) History of venous thromboembolism, pulmonary embolism, cerebral infarction, coronary heart disease; (9) Patients with severe liver and kidney dysfunction.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood loss;Drainage;ESR, CRP, IL-6, IL-10; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hb;Hct;DVT, PE;Transfusion;Swelling;VAS pain score;color Doppler Ultrasonic (CDU) examination in lower extremity;ROM;Muscle strength;Coagulation index;Satisfaction scores;Sleep quality; | — |
Countries
China
Contacts
Public ContactJian Li
West China Hospital, Sichuan University
Outcome results
None listed