Depression and other common mental disorder
Conditions
Interventions
Case group versus normal group:Nil
Sponsors
Department of Psychosomatics and Psychiatry, Southeast University Affiliated Zhongda Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: MDD inclusion criteria: 1. Patients who meet the diagnostic criteria of MDD in DSM-IV; 2. Patients with Hamilton Depression Scale 17 item (HAMD-17) score = 17; 3. Patients aged 18-60; 4. Patients with no history of electroconvulsive therapy; 5. Right handed patients. Normal control (HC) inclusion criteria: 1. The sex, age and education level of the patients match with those of the patients. The HAMD-17 score is less than 8 (and the "depression" score is 0); 2. Subjects with no history of severe gravity, brain and kidney diseases, alcohol and drug abuse, and family history of mental diseases; 3. Patients without pacemaker or metal material can be examined by MRI. T2 weighted MRI does not show cerebral infarction or other vascular damage; 4. Right handed objects.
Exclusion criteria
Exclusion criteria: MDD exclusion criteria: 1. Patients with serious suicidal tendency; 2. Patients who had taken mood stabilizers, antipsychotics or any antidepressants within 2 weeks before admission; 3. Patients with previous history of other mental diseases; 4. Patients with obvious abnormality in laboratory and auxiliary examination; 5. Patients who do not cooperate with the examination or fail to complete the examination due to the disturbance of consciousness or vision, hearing, language expression and understanding; 6. Patients with primary brain tumor, brain metastasis, brain injury, multiple sclerosis or severe body disease (including severe cardiopulmonary, hepatorenal insufficiency, shock, malignant tumor or hematopathy, autoimmune disease); 7. Patients with cerebral infarction or other vascular injury on T2 weighted MRI; 8. Patients with pacemakers or metal materials in the body that cannot be examined by MRI.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MRI;Peripheral blood protein index;Clinical scale; | — |
Countries
China
Contacts
Public ContactYuan Yonggui
Southeast University Affiliated Zhongda Hospital
Outcome results
None listed