senile disease
Conditions
Interventions
Case series:Nil
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
65 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. both genders; 2. aged >=60 years; 3. capacity to give informed consent and follow study procedures.
Exclusion criteria
Exclusion criteria: 1) known diagnosis of severe disease that are life-threatening with expected life expectancy of less than six months; 2) severe visual or auditory deficits that may interfere with the completion of cognitive function and physical frailty assessments; 3) patients with contraindications for the MRI and PET scan: claustrophobia, metallic materials, carriers of non-compatible pacemaker, internal defibrillator or other ferromagnetic implants not allowing going to the service of neuroimaging; 4) patients with severe cognitive impairment (MoCA 20); 6) severe cardiac dysfunction: acute decompensated heart failure and/or chronic heart failure functional class III or IV (New York Heart Association classification); 7) severe pulmonary dysfunction: acute exacerbation of chronic obstructive lung disease stage III or IV (GOLD classification), and/or PaO2 levels < 60 mmHg; 8) history of Parkinson's; 9) a history of head trauma or fainting; 10) currently using sleeping aids, painkillers (including aspirin), or other agents known to affect brain function (for instance, antihistamines, decongestants, etc.).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Magnetic Resonance Imaging;physical frailty; | — |
Secondary
| Measure | Time frame |
|---|---|
| frailty biomarkers; | — |
Countries
China
Contacts
Public ContactXin Xia
West China Hospital, Sichuan University
Outcome results
None listed