Type 2 diabetes
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1. T2DM patients according to who (1999) diabetes diagnosis; 2. Patients over 18 years old; 3. Patients who had no change in oral antidiabetic drugs or insulin half a month before the intervention; 4. Patients with clear awareness, normal communication and willing to participate in the study and sign informed consent.
Exclusion criteria
Exclusion criteria: 1. Regular consumption of nuts >= 4D / W; 2. Those who are allergic to food (especially nuts) or in other diet treatment; 3. Subjects with less teeth and difficult to chew; 4. Patients with serious dyspepsia, heart failure, renal failure, malignant tumor, serious cerebrovascular disease, ketosis, hyperthyroidism, digestive dysfunction, liver dysfunction or serious gallbladder and pancreatic diseases; 5. Subjects with fasting blood glucose >= 16.7; 6. Objects suffering from mental illness; 7. Patients who use antidepressants, anxiety, neuroleptics or psychoactive drugs; 8. Pregnant and lactating women; 9. Patients taking glucocorticoids; 10. Subjects who take drugs, supplements (such as antibiotics, probiotics) and yoghurt that affect the composition of intestinal flora in the past three weeks.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Depression score;Gut microbiota; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cognitive Function;Global Health score;Diabetes Distress score;glycosylated hemoglobin;fasting blood-glucose;GLP-1; | — |
Countries
China
Contacts
The First Affiliated Hospital of Soochow University