Total hip arthroplasty
Conditions
Interventions
Group K1:Perioperative use of esketamine
Group K2:Perioperative and postoperative analgesia pumps use of esketamine
Sponsors
The First Affiliated Hospital of Zhengzhou University
Eligibility
Sex/Gender
All
Age
45 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Patients to be treated with hip replacement; 2. Patients with ASA grade I-III; 3. Patients aged 45-75 years; 4. Patients with body mass index (BMI) < 30; 5. Patients willing to sign informed consent of anesthesia.
Exclusion criteria
Exclusion criteria: 1. Patients with bone tumor; 2. Patients who are allergic to the study drug; 3. Patients with severe hypertension and liver and kidney dysfunction; 4. Patients with long-term opioid use, alcohol or drug abuse; 5. Patients with consciousness disorder or severe mental and nervous system diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| VAS score;Postoperative analgesic pump dosage;Patien Health Questionnare;Generalized Anxiety Disorder, GAD-7;Postoperative recovery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Plasma inflammatory factor levels;Nausea, headache, dizziness, blurred vision, hallucinations, nightmares; | — |
Countries
China
Contacts
Public ContactAi Yan-qiu
The First Affiliated Hospital of Zhengzhou University
Outcome results
None listed