The relationship between the occurrence of perioperative neurocognitive disorders (PND) and intestinal microbial flora in elderly patients after lower limb joint replacement

Status

Recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2000031958

Enrollment

Unknown

Registered

2020-04-16

Start date

2020-04-20

Completion date

Unknown

Last updated

2020-04-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

perioperative neurocognitive disorders (PND)

Interventions

POD group vs non-POD group:N/A

Eligibility

Sex/Gender

All

Age

65 Years to 99 Years

Inclusion criteria

Inclusion criteria: meet the following conditions can be considered for inclusion: (1) over 65 years old; (2) Knee or hip replacement; (3) Receive general anesthesia; (4) hearing and vision are good enough to complete the scales; (5) Can communicate with medical staff in Mandarin or Cantonese.

Exclusion criteria

Exclusion criteria: Exclude from the group if: (1) Severe cardiopulmonary disease; (2) Above ASA3; (3) Serious complications were transferred to ICU; (4) Depression (PHQ9:> 5 points); (5) Dementia (MMSE: illiteracy 7 points); (7) Cognitive Impairment (CAM> 19 points); (8) Joint revision; (9) Bilateral joint replacement; (10) Patients with IBD and other intestinal disorders; (11) took antibiotics within 3 months; (12) Alcohol, alcohol-related disease.

Design outcomes

Primary

Measure	Time frame
POD;	—

Secondary

Measure	Time frame
DNR;NCD;	—

Countries

China

Contacts

Public ContactXia Feng

The First Affiliated Hospital, Sun Yat-Sen University

fengxia@mail.sysu.edu.cn+86 13688877856

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026