diabetes
Conditions
Interventions
experimental group:Liraglutide combined with dietary intervention
Sponsors
Beijing Hospital, National Center of Gerontology
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Subjects must meet all the following criteria to be enrolled: type 2 diabetes patients who are 18 years old or older and 65 years old or older, WHO (1999) diabetes diagnosis criteria, BMI >= 28KG / m2, HbA1c 7.5% ~ 9%, signing informed consent and complying with the study protocol.
Exclusion criteria
Exclusion criteria: Subjects were excluded from the study if any of the following exclusion criteria were met: 1. Patients who used DPP4 inhibitors in the past three months; 2. Patients who had acute metabolic complications in the six months before screening, including lactic acidosis, non ketotic hyperosmotic coma, diabetic ketoacidosis; 3. Patients with serious acute and chronic complications of diabetes (such as myocardial infarction, cerebrovascular accident, congestive heart failure, as seen by diabetes) Blindness, renal failure and severe foot ulcer caused by omentum disease); 4. Those with endocrine diseases other than type 2 diabetes who are being treated and not under control; 5. Severe hypoglycemia with repeated attacks judged by the researchers; 6. Severe liver function damage (ALT >= 3uln); 7. Severe renal insufficiency; heart failure (NYHA III ~ IV); 8. Severe hyperglycemia Patients with mental disorders, pregnant and lactating women, high-risk factors of medullary thyroid cancer, tumor history within 5 years, and allergic to lilalutide and its adjuvants.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intramuscular fat content; | — |
Countries
China
Contacts
Public ContactDongni Yu
Department of Endocrinology, Beijing Hospital, National Center of Gerontology
Outcome results
None listed