Pure red blood cell aplastic anemia after kidney transplant
Conditions
Interventions
case series:Foscarnet ( IV.)
Sponsors
The First Affiliated Hospital of Zhejiang University School of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) Voluntary informed consent, any age and gender; (2) Intractable moderate to severe anaemia after kidney transplantation; (3) qPCR positive for microbial B19 virus nucleic acid; (4) Hemoglobin <100g/L and reticulocytes <0.5%; (5) Patients routinely taking triple antiimmune drugs after surgery; (6) Preoperative population-reactive antibody (PRA) negative, no fever and significant anaemia; (7) All donor and recipient HBV-DNA, CMV-IgG, CMV-IgM, CMV-DNA, HIV- IgG and syphilis tests were negative; (8) All transplants were successful and postoperative renal function was well restored; (9) The ability of the patient to follow the study protocol as determined by the investigator.
Exclusion criteria
Exclusion criteria: (1) An allergic body with a known allergy to sodium phosphonate or 2 or more other drugs or foods used by injection; (2) Multi-organ transplant, multiple transplants; (3) Loss of early transplanted kidneys; (4) Moderate and severe anaemia due to surgical bleeding, bone marrow suppression, hematologic disorders, etc.; (5) Pregnant or lactating women; (6) In the judgment of the investigator, there are other factors that may cause the subject to be forced to discontinue the study, such as other serious illnesses, serious laboratory abnormalities, other factors that affect the safety of the subject or the collection of test information and blood samples.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| hemoglobin; | — |
Secondary
| Measure | Time frame |
|---|---|
| virus copy number;reticulocyte;blood creatinine; | — |
Countries
China
Contacts
Public ContactPENG WENHAN
The First Affiliated Hospital of Zhejiang University School of Medicine
Outcome results
None listed