Major depressive disorder
Conditions
Interventions
Patient:Antidepressants (sertraline, esitalopram, venlafaxine)
Control:None
Sponsors
Fudan University
Eligibility
Sex/Gender
All
Age
16 Years to 45 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria for patients with depression: 1. Meet DSM-4 diagnostic criteria for depression (symptom criteria 9, disease course criteria more than 2 weeks, severe criteria with pain and functional impairment, excluding other causes or diseases); 2. HAMD - 17 17 or more; 3. First attack; 4. Not treated with antidepressants or benzodiazepines. Or not taking medication for nearly a week; 5. Ages 16-45 years; 6. No less than 9 years of education; 7. Both parents and three generations are Han Chinese; 8. Understand and sign informed consent; Inclusion criteria of healthy volunteers: 1. Aged 16-45 years (age and sex ratio matched with patients); 2. No less than 9 years of education (education level and patient matching); 3. Both parents and three generations are han Chinese; 4. No history of mental illness; 5. Hamd-17 <=7, BDI<=45; 6. Not meeting DSM-iv diagnostic criteria; 7. Denying serious physical diseases (such as cardiovascular, cerebrovascular, liver and kidney diseases); 8. Understand and sign informed consent.
Exclusion criteria
Exclusion criteria: Exclusion criteria for patients with depression: 1. Have other mental disorder; 2. Pregnant and lactating women; 3. Taking antidepressants or receiving treatment for other types of mental illness in the past 6 months; 4. Substance abuse in the past 6 months; 5. A history of organic brain disease; 6. Have been unconscious for more than 10 minutes with a head injury; 7. Contraindications in mri testing; 8. The ability of action, sight, hearing and understanding cannot meet the demand of data collection of the subject; 9. Poor compliance makes it impossible to complete follow-up; 10. IQ Lower than 70. Exclusion criteria for healthy volunteers: 1. Have a mental disorder; 2. Pregnant and lactating women; 3. Substance abuse in the past 6 months; 4. A history of organic brain diseases; 5. Have been unconscious for more than 10 minutes with a head injury; 6. Contraindications in mri testing; 7. The ability of action, sight, hearing and understanding cannot meet the demand of data collection of the subject; 8. IQ Lower than 70; 15. Compliance is poor and follow-up is unlikely to be completed.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MRI;Webster adult intelligence scale(WASI);Environmental factor assessment scale;Hamilton Depression Rating Scale (HAM-D);Hamilton Anxiety Rating Scale (HAM-A);Beck Depression inventory, BDI;Temporal Experience of Pleasure Scale, TEPS;Beck Anxiety Inventory, BAI;WHO Quality of Life Scale, WHOQOL-BF;Beck Scale for Suicide Ideation, BSS;Barratt Impulsiveness Scale (BIS);Personality Diagnostic Questionnaire-4+, PDQ-4+;Negative cognitive processing bias questionnaire, CMNCB;cognitive emotion regulation questionnaire, CERQ;Attributional Style Questionnaire, ASQ;The Childhood Trauma Questionnaire, CTQ;Life Event Scale, LES;social support revalued scale, SSRS; | — |
Countries
China
Contacts
Public ContactQiang Luo
Fudan University
Outcome results
None listed