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Effect of Ringer's sodium bicarbonate injection on MAKE30 in critically ill patients with shock: a multicenter prospective, open controlled study

Effect of Ringer's sodium bicarbonate injection on MAKE30 in critically ill patients with shock: a multicenter prospective, open controlled study

Status
Recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2000031926
Enrollment
Unknown
Registered
2020-04-14
Start date
2020-04-01
Completion date
Unknown
Last updated
2020-09-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

critical shock

Interventions

control group:saline
test group:Sodium bicarbonate Ringer injection

Sponsors

The First People's Hospital of Lianyungang
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Age 18 years or older (including 18 years old), 75 years old or younger (excluding 75 years old), male or female; 2. Patients with blood loss, trauma, burns or septic shock admitted to EICU during the study period; 3. SOFA score (see Appendix 1. for details) cardiovascular system score >= 2; 4. Blood lactic acid > 2.0mmol / L;

Exclusion criteria

Exclusion criteria: 1. People with possible brain injury (or hospitalization due to brain trauma); 2. Patients with known creatinine clearance < 40ml / min or expected to need CRRT; 3. Patients with the following serious underlying diseases: NYHA heart failure grade 2 or higher; active myocardial ischemia or percutaneous coronary intervention in the past 60 days; clear history of liver cirrhosis (Child-Pugh score B or higher, (See Attachment 2. for details); severe COPD requires home oxygen therapy; long-term use of hormones or clear AIDS; 4. Patients with known hypermagnesemia; 5. Known hypothyroidism; 6. Lactating, pregnant women; 7. Patients expected to die in the short term; 8. Researchers do not consider it appropriate to participate in this research.

Countries

China

Contacts

Public ContactXiaominli

The First People's Hospital of Lianyungang

zwpharma@163.com+86 18961329000

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026