perioperative regional anesthesia and analgesia
Conditions
Interventions
Sponsors
Peking University First Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Participants meet all of the following criteria will be enrolled in this study: (1) Age between 18 and 75 years; (2) Plan to undergo LRNU; (3) Agree to receive regional nerve block and postoperative intravenous controlled analgesia (PCIA); (4) American Society of Anesthesiologist physical status Classification I-III; (5) Agree to participate in the study and signed the informed consent.
Exclusion criteria
Exclusion criteria: (1) BMI > 35kg/m2 or 442µmol/L or requirement of renal replacement therapy), liver dysfunction (Child-Pugh Class C) and heart failure; (3) Contraindication of deep nerve block, including but not limited to be allergic to anesthetic drug, coagulation disorder, infection at the injection site; (4) Chronic opioids dependence and long-term use of various analgesics for chronic pain over 3 months; (5) Unable to communicate preoperatively due to severe dementia, language barrier or neuropsychiatric disorder, or else; (6) Unable to perform nerve block procedure due to difficult anatomy through ultrasound scan.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| a joint endpoint of cumulative 24h opioids consumption after surgery and average pain NRS score at 24th h (valued the average from NRS at rest and with movement at 24th h) postoperatively.; | — |
Secondary
| Measure | Time frame |
|---|---|
| cumulative opioids consumption at different time (0.5h, 2h, 6h, 18h, 24h and 48h) after surgery;somatic and visceral NRSpain scores both at rest and with movement at 0.5th h, 2nd h, 6th h, 18th h, 24th h, 48th h postoperatively;the time interval to the first bolus demand in PCIA pump;the numbers of required boluses in PCIA pump;the numbers of administered boluses in PCIA pump;the numbers of rescue analgesia besides PCIA pump; | — |
Countries
China
Contacts
Public ContactHong Zhang
Peking University First Hospital
Outcome results
None listed