Recurrent Wheezing
Conditions
Interventions
daily group:initially given inhaled BUD 1 mg once a day, assessed every 4 weeks
if the symptom was well controlled and maintained for 12 weeks, the dose was reduced to 25%-50% of the previous dose until the final dose was 0.25 mg, once a day, maintained to 52 weeks)
an intermittent high-dose group:1 mg twice daily for 7 days, starting early during a predefined respiratory tract illness
an intermittent medium-dose group:0.5 mg twice daily as soon as they contacted allergens or had nasal congestion, a runny nose, cough or any other suspicious respiratory symptoms, continuing until the
Sponsors
The First Affiliated Hospital of Nanchang University
Eligibility
Sex/Gender
All
Age
1 Years to 5 Years
Inclusion criteria
Inclusion criteria: 1. mAPI positive children; 2. have >=4 wheezing episodes in the past year; 3. meeting at least 1 major criterion or at least 2 minor criteria. The major criteria include parental history of asthma, physician-diagnosed atopic dermatitis, and allergic sensitization to at least 1 aeroallergen. The minor criteria include wheezing unrelated to colds, peripheral blood eosinophils >=4%, and allergic sensitization to milk, egg, or peanuts.
Exclusion criteria
Exclusion criteria: 1. their wheezing was caused by organic lesions and mechanical factors; 2. had received more than six systemic glucocorticoids or had been hospitalized more than two times within 52-weeks; 3. had used other asthma control drugs; 4. their guardians did not know the childs medical history or did not agree to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The Test for Respiratory and Asthma Control in Kids scores; | — |
Secondary
| Measure | Time frame |
|---|---|
| the number of systemic corticosteroids courses during the 52-week treatment period.;the number of wheezing episodes during the 52-week treatment period.;urgent care visits for wheezing during the 52-week treatment period.; | — |
Countries
China
Contacts
Public ContactPing Sun
The First Affiliated Hospital of Nanchang University
Outcome results
None listed