Ischemic Stroke
Conditions
Interventions
MRI Group:The indication for endovascular therapy was determined solely based on MR imaging findings. Patients exhibiting FVH-DWI mismatch on multimodal MRI received endovascular therapy plus optimal
Perfusion Group:Indications for endovascular therapy were determined exclusively based on perfusion imaging findings. Patients meeting the DEFUSE 3-defined perfusion mismatch criteria (ischemic core v
Sponsors
Tianjin Huanhu Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age of 18 years or older; 2. Anterior circulation LVO (internal carotid artery, or middle cerebral arteries (MCA)M1, M2 proximal segment) confirmed by computed tomographic angiography (CTA)/ magnetic resonance angiography (MRA); 3. NIHSS score =6 at the time of randomization; 4. Time from stroke onset to randomization within 6-24 hours; 5. Pre-stroke mRS score 0-2; 6. Completed MRI and perfusion imaging or could cooperate to complete MRI and/or perfusion imaging; 7. Signed informed consent.
Exclusion criteria
Exclusion criteria: 1. ASPECTS score 3 or PPT > 3 times normal); 5. Active hemorrhage or preexisting tendency to hemorrhage; 6. Presence of signs of cardiac, hepatic or renal failure; 7. Participation in other interventional randomized clinical trial that may confound the outcome assessment of the trial; 8. Life expectancy < 1 year; 9. A stroke attack with epilepsy that prevents an accurate NIHSS score from being obtained; 10. Multiple large vessel occlusion; 11. Other circumstances that the investigator considers inappropriate for participation in the trial (such as violation of guidelines or institutional processing principles during the screening process); 12. CTA/MRA shows vascular anatomy is severely tortuous, has an anatomic variation that would preclude the navigation of the thrombectomy devices to the target vessel.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Functional independence(modified Rankin Scale(mRS) 0-2); | — |
Secondary
| Measure | Time frame |
|---|---|
| NIHSS scores at 24h after randomization;NIHSS scores at 7 days or at discharge (whichever was earlier) ;Proportion of patients functionally independent of daily activities (defined as Barthel index >95) ;Infarct volume;Repass rate;EQ-5D evaluates the quality of health survival;Length of hospitalization;Symptomatic intracranial hemorrhage;Any intracranial hemorrhage;Mortality rate; | — |
Countries
China
Contacts
Public ContactWei Ming
Tianjin Huanhu Hospital
Outcome results
None listed